Datasheet1_The association of relative humidity and air pollution interaction on lung function in adolescents.docx

BackgroundRelative humidity (RH) and air pollution significantly affect respiratory health. However, how RH and air pollution interact and modify each other and affect lung function in adolescence is largely unknown. This study assesses the interactive association of RH and air pollution on lung function, i.e. forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), in German adolescents.MethodsA total of 2,116 participants with available spirometry measurements (z-scores of FEV1 and FVC) were included from the 15-year follow-up of the German GINIplus and LISA birth cohort. Daily environmental exposure data included RH, ozone (O3), nitrogen dioxide (NO2), and particulate matter

背景相对湿度（RH）及空气污染对呼吸健康具有显著影响。然而，相对湿度与空气污染之间的相互作用及其对青少年肺功能的影响，即最大通气量（FVC）和一秒用力呼气量（FEV1），目前尚不明确。本研究旨在评估相对湿度与空气污染对德国青少年肺功能（FVC和FEV1）的交互作用。方法部分，共纳入了2116名具有可用肺功能测量值（FEV1和FVC的Z分数）的参与者，这些参与者来自德国GINIplus和LISA出生队列的15年随访研究。每日环境暴露数据包括相对湿度、臭氧（O3）、二氧化氮（NO2）和颗粒物。