Reproducibility between studies.

Data shown are for the entire control group (all) for six independent efficacy studies in the SOD1G93A transgenic mouse model of ALS, as well as the data for male (m) and female (f) mice in each study. Study details are given in table 1. Each parameter is measured in age (days) +/− standard deviation. ‘Onset’ is age in days at which both hind-limb splay and tremor were first obvious; ‘Survival’ is age in days to humane end-point (loss of righting reflex for more than 10 seconds or weight loss of >30% for >72 hours), ‘Rotarod’ is the age in days at which a 20% reduction in rotarod performance compared to baseline was first seen. For each parameter the coefficient of variation (CV) is also shown. This is the standard deviation expressed as a percentage of the mean. These parameters are not comparable either because different criteria were applied or the data were not collected; nd-not determined, nk-not known.