Estrogen receptor mutant L536S
收藏Protein Data Bank Japan2024-05-15 更新2026-03-21 收录
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https://pdbj.org/mine/summary/6sbo
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资源简介：
Estrogen receptor mutant L536S Descriptor: 6-(2,4-dichlorophenyl)-5-[4-[(3~{S})-1-(3-fluoranylpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7~{H}-benzo[7]annulene-2-carboxylic acid, Estrogen receptor Authors: Vallee, F, Steier, V, Rak, A. Deposit date: 2019-07-22 Release date: 2019-11-27 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer. J.Med.Chem., 63, 2020
创建时间：
2019-07-22
