RNA-seq comparison of primary mouse classical brown, beige, and white adipocytes. RNA-seq comparison of primary mouse classical brown, beige, and white adipocytes

Classical brown adipocytes in interscapular BAT (Myf-5 derived) and "inducible" beige cells in WAT (non-Myf-5 derived) have distinct developmental origins, although both cell types have morphological and biochemical characteristics of brown fat such as the expression of UCP1. This raises an important question as to how similar the two types of brown adipocytes are at molecular and functional levels. To this end, we employed RNA-seq to systematically determine the transcriptional signatures unique to each cell type.