Geniposide suppressed tumor progression through DUOX1-mediated ferroptosis in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) poses a formidable challenge within the spectrum of digestive system cancers due to its poor prognosis. Geniposide, an iridoid glucoside extracted from the fruits of Gardenia jasminoides Ellis, exhibits a diverse array of biological activities. The objective of this study is to delineate the specific roles and underlying mechanisms of geniposide on the progression of HCC. Huh7 and HepG2 cells were subjected to treatment with or without geniposide for 48 h, after which they were collected for transcriptome sequencing