Supplementary Files.

<b>Supplementary Datasheet 1. </b>SNPs numbers of GM and GM-associated metabolites for four outcomes.<b>Supplementary Datasheet 2.</b> Causal effects of all GMs and GM-associated metabolites on four outcomes.<b>Supplementary Datasheet 3. </b>Sensitivity and causal direction analysis results including all GMs.<b>Supplementary Datasheet 4. </b>Sensitivity and causal direction analysis results including all GM-associated metabolites.<b>Supplementary Datasheet 5. </b>SNPs used for inflammatory factor mediation analysis.<b>Supplementary Datasheet 6. </b>SNPs used for immune cell mediation analysis.<b>Supplementary Datasheet 7. </b>SNPs used for plasma protein mediation analysis.<b>Supplementary Datasheet 8. </b>SNPs information supplementary of significant causal associations between GMs or associated metabolites and outcomes.<b>Supplementary Datasheet 9. </b>Basic information of clinical patients included in this research.<b>Supplementary Table 1.</b> Numbers of GM types at different taxonomic levels and corresponding Bonferroni-corrected significance thresholds.<b>Supplementary Figure 1. </b>Statistical analysis of clinical patient basic information. <b>(A-D).</b> Statistical analysis of IVDD patient basic information<b>.(E-H).</b> Statistical analysis of CDD patient basic information.