The FK1 domain of FKBP51 in complex with SAFit-analog 15b
收藏资源简介：
The FK1 domain of FKBP51 in complex with SAFit-analog 15b Descriptor: (2-methyl-1,3-thiazol-5-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 Authors: Meyners, C, Buffa, V, Hausch, F. Deposit date: 2024-03-27 Release date: 2024-06-12 Last modified: 2024-09-11 Method: X-RAY DIFFRACTION (2.21 Å) Cite: 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
与SAFit类似物15b结合的FKBP51的FK1结构域，描述信息：(2-甲基-1,3-噻唑-5-基)甲基 (2S)-1-[(2S)-2-环己基-2-(3,4,5-三甲氧基苯基)乙酰基]哌啶-2-羧酸酯，肽基脯氨酰顺反异构酶（Peptidyl-prolyl cis-trans isomerase）FKBP5 作者：Meyners C、Buffa V、Hausch F 存放日期：2024-03-27 发布日期：2024-06-12 最后修改日期：2024-09-11 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.21埃（Å） 引用文献：含1,4-吡唑基的SAFit类似物为兼具优化配体效率与类药特性的选择性FKBP51抑制剂。《Chemmedchem》，19卷，2024年
