Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)

Protein Data Bank Japan2023-12-20 更新2026-03-21 收录

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Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) Descriptor: 1,2-ETHANEDIOL, 5-METHYL-3-PHENYL-1H-PYRAZOLE, NITRATE ION, ... Authors: Silva-Santisteban, M.C, Westwood, I.M, Boxall, K, Brown, N, Peacock, S, McAndrew, C, Barrie, E, Richards, M, Mirza, A, Oliver, A.W, Burke, R, Hoelder, S, Jones, K, Aherne, G.W, Blagg, J, Collins, I, Garrett, M.D, van Montfort, R.L.M. Deposit date: 2012-10-05 Release date: 2013-06-26 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. Plos One, 8, 2013

基于片段的筛选发现细胞周期检查点激酶2（checkpoint kinase 2, CHK2）抑制剂结合的新区域 Descriptor: 1,2-乙二醇（1,2-ETHANEDIOL）、5-甲基-3-苯基-1H-吡唑（5-METHYL-3-PHENYL-1H-PYRAZOLE）、硝酸根离子（NITRATE ION）等。 Authors: Silva-Santisteban, M.C.、Westwood, I.M.、Boxall, K.、Brown, N.、Peacock, S.、McAndrew, C.、Barrie, E.、Richards, M.、Mirza, A.、Oliver, A.W.、Burke, R.、Hoelder, S.、Jones, K.、Aherne, G.W.、Blagg, J.、Collins, I.、Garrett, M.D.、van Montfort, R.L.M. Deposit date: 2012-10-05 Release date: 2013-06-26 Last modified: 2023-12-20 Method: X射线衍射（X-RAY DIFFRACTION, 2.7 Å） Cite: 《基于片段的筛选绘制细胞周期检查点激酶2 ATP结合位点内的抑制剂相互作用图谱》，《公共科学图书馆·综合》，第8卷，2013年

创建时间：

2012-10-05