Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a dichloro-substituted, 3-methyl 2,5-diarylthiophene-core ligand 4,4'-(3-methylthiene-2,5-diyl)bis(3-chlorophenol)

Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a dichloro-substituted, 3-methyl 2,5-diarylthiophene-core ligand 4,4'-(3-methylthiene-2,5-diyl)bis(3-chlorophenol) Descriptor: 4,4'-(3-methylthiene-2,5-diyl)bis(3-chlorophenol), Estrogen receptor, Nuclear receptor coactivator 2 Authors: Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. Deposit date: 2015-09-15 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016

本数据集为与二氯取代的3-甲基2,5-二芳基噻吩骨架配体4,4'-(3-甲基噻吩-2,5-二基)双(3-氯苯酚)结合的雌激素α受体（ER-alpha）配体结合域的晶体结构。数据集描述信息如下：配体为4,4'-(3-甲基噻吩-2,5-二基)双(3-氯苯酚)，研究对象为雌激素受体（Estrogen receptor）与核受体辅激活因子2（Nuclear receptor coactivator 2）；作者为Nwachukwu, J.C、Srinivasan, S、Zheng, Y、Wang, S、Min, J、Dong, C、Liao, Z、Cavett, V、Nowak, J、Houtman, R、Carlson, K.E、Josan, J.S、Elemento, O、Katzenellenbogen, J.A、Zhou, H.B、Nettles, K.W.；沉积日期：2015-09-15，发布日期：2016-05-04，最后修改日期：2023-09-27；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率为2.07埃（Å）；引用文献：《通过雌激素受体的配体特异性信号传导的预测特征》，发表于《Mol.Syst.Biol.》第12卷，2016年。