From clinical to benchside: Lacticaseibacillus and Faecalibacterium are positively associated with muscle health and alleviate age-related muscle disorder

To investigate its role in sarcopenia, we (i) compared gut microbiota and metabolite composition between older persons with and without sarcopenia, (ii) performed fecal microbiota transplantation (FMT) from human donors to antibiotic-treated mice, and (iii) identified two specific probiotics for treatment of sarcopenia in aged mice. The results showed that older persons with sarcopenia had distinctive gut microbiota characteristics, and muscle-related probiotics enhanced muscle status of aged mice through mitochondria improvement. Attention: The manuscript is under review of journal publication, please cite any data from this study after the publication of the manuscript.