Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Knockout Mice. Mus musculus

Hepatocellular carcinoma (HCC) is the fourth most common cancer worldwide and is associated with a poor prognosis. We performed NGS-based transcriptome analysis between WT and KO liver tumour tissues to understand deletion of ChREBP delays insulin-induced hepatocarcinogenesis, which suggests a combined oncogenic and lipogenic function of ChREBP along AKT/mTOR-mediated proliferation of hepatocytes and induction of hepatocellular carcinoma.