GEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition. GEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition

The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKe Overall design: Examination of MDP stimulated BMDM from WT, Arhgef2 and Irf5 KO mice