structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease

structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease Descriptor: 4-[1-[3-[4-[(4-fluoranyl-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-quinazolin-7-yl]oxypropyl]piperidin-4-yl]benzamide, 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit 1, ... Authors: Bao, R, Luo, Y.F, Zhu, Y.B, Yang, Y, Zhou, Y.Z. Deposit date: 2022-03-15 Release date: 2023-04-12 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (3.24 Å) Cite: Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors J.Med.Chem., 66, 2023

西地尼布（Cediranib）靶向结核分枝杆菌（Mycobacterium tuberculosis）ClpP1P2的抑制作用的结构解析：靶向Clp蛋白酶的抗菌药物开发启示
Descriptor：4-[1-[3-[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-6-甲氧基-喹唑啉-7-基]氧基丙基]哌啶-4-基]苯甲酰胺、4-[[3,5-二氟苯基]甲基]-N-[(4-溴苯基)甲基]哌嗪-1-甲酰胺、ATP依赖型Clp蛋白酶水解亚基1等
Authors：Bao, R、Luo, Y.F、Zhu, Y.B、Yang, Y、Zhou, Y.Z
Deposit date：2022-03-15
Release date：2023-04-12
Last modified：2024-04-24
Method：X射线衍射（X-RAY DIFFRACTION），分辨率3.24 Å
Cite：引用文献：《新型结核分枝杆菌ClpP1P2抑制剂的发现及其机制研究》（Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors），刊载于《Journal of Medicinal Chemistry》（J.Med.Chem.），2023年，第66卷