Synthesis of Active Hexafluoroisopropyl Benzoates via a Multicomponent Reaction

Herein, we describe an efficient,
practical free-metal rapid access
to active hexafluoroisopropyl benzoates from anthranils, hexafluoroisopropanol,
and N-alkoxy α-halogenoacetamides. Notably,
this process includes anthranils that underwent a distinct pattern
reaction. The protocol has good functional group tolerance and a broad
substrate scope. Using a simple and general method, we accomplished
potential synthetic application of active ester.