FKBP51 in complex with tricyclic ligands
收藏DataCite Commons2024-04-09 更新2025-04-15 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-DC-1602472053
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资源简介：
FK506-binding proteins hold high potential as drug targets but the scope of usable scaffolds for the generation of high affinity ligands is limited. Here we used structure-based optimization to discover tricyclic FKBP ligands with picomolar biochemical and subnanomolar cellular activity that represent the most potent FKBP ligands known to date.
提供机构：
European Synchrotron Radiation Facility
创建时间：
2024-04-09
