The effect of skyrin in normoxia and hypoxia on HCT 116 cell line

Skyrin is a plant secondary metabolite from Hypericum genus with potential in anticancer therapy. It is structurally very similar to hypericin. The mechanism of its action in normoxia as well as in hypoxia, when cells are expressing multiple adaptive mechanisms connected to poor prognosis, could be very interesting. To achieve it, label-free comparative proteomic analysis of HCT 116 cell lines samples was performed.