p38a bound with SR92

p38a bound with SR92 Descriptor: 1,2-ETHANEDIOL, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-oxidanylidene-1-(pyridin-4-ylmethylamino)butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 Authors: Schroeder, M, Roehm, S, Knapp, S, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Structural Genomics Consortium (SGC) Deposit date: 2020-07-28 Release date: 2020-08-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020

结合了SR92的p38α蛋白。描述符：1,2-乙二醇（1,2-ETHANEDIOL）、5-氨基-N-[4-[[(2S)-4-环己基-1-氧代-1-(吡啶-4-基甲基氨基)丁烷-2-基]氨基甲酰]苄基]-1-苯基吡唑-4-甲酰胺、丝裂原活化蛋白激酶14（Mitogen-activated protein kinase 14）。作者：Schroeder M、Roehm S、Knapp S、Arrowsmith C.H.、Bountra C、Edwards A.M.，以及结构基因组学联合会（Structural Genomics Consortium, SGC）。数据存放日期：2020-07-28；发布日期：2020-08-12；最后修改日期：2024-01-31。解析方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.9埃（Å）。引用文献：《选择性靶向p38丝裂原活化蛋白激酶的αC螺旋与DFG-out口袋》，《Eur.J.Med.Chem.》，208卷，2020年