Differential expression of gene was analyzed after FLI1 silencing in Ewing Sarcoma cell line A673. Overall design: Cells were transfected with either siRNA -scrambeled (si-con) or siRNA-FLI1 oligonucl
PARP inhibitors have gained attention in the treatment of metastatic castration-resistant prostate cancer, but approximately half of patients have to abort treatment due to severe hematological toxici
The androgen receptor (AR) is the best studied drug target for the treatment of prostate cancer. While there are a number of drugs that target the AR, they all work through the same mechanism of actio
Castration-resistant prostate cancer (CRPC) remains a significant therapeutic challenge with limited effective treatment options. We identified retinoid X receptor γ (RXRγ) as a critical regulator of
