Genetic characterization of a missense mutation in the X-linked TAF7L gene in an oligozoospermic man

We carried out genome-wide expression profiling by RNA-seq to determine whether the mutation brings about a certain influence to the transcriptomic homeostasis. Indeed, there were some differential expressions of mRNA and noncoding genes in comparison of the Taf7lD144G and wide-type testis, lending support to mutation-caused defects at molecular level. Examination of transcriptome profiling coding and noncoding gene of adult wild type(WT) and taf7l mutant mice testis