Effect of Se on the liver metabolism in mice via RNA-seq

The synthesis mechanisms and function evaluation of selenium(Se)-enriched microorganism remain relatively unexplored. Selenium exists in two predominant forms within A. oryzae A02: selenoproteins (SeMet 32.1%, SeCys 14.4%) and selenium nanoparticles (SeNPs; 53.5%). To assess the regulatory impact of SeNPs on mice metabolism and scrutinize its potential regulatory mechanisms, we administered SeNPs to mice for 8 weeks and scrutinized its effects on growth performance and liver physiological metabolism.