Two-Stage Meta-Regression Framework for Precision Medicine Using Data from Clinical Data Research [Methods Study], United States, 2018-2023

Network meta-analysis, or NMA, is a statistical method that researchers use to combine results from many clinical trials done within a research network. A research network is a group of scientists and doctors from different places, like hospitals and research centers, who do studies together and share data. Researchers can use NMA to compare how well different treatments work for a specific health problem. But current NMA methods don't work well when comparing three or more treatments across many health outcomes.
In this study, the research team developed new NMA methods to compare three or more treatments that bring on labor to start the process of childbirth across many health outcomes using research network data.