[68Ga]Ga-Pentixafor PET/CT images of Glioma patients

This dataset contains information showing chemokine receptor-4 (CXCR4) targeting in high-grade glial brain tumors in treatment-naïve adult patients using a novel radiolabeled PET tracer; [68Ga]Ga-CXCR4 PET/CT. The enrolled patients received the radiotracer intravenously. After approximately 60 minutes, the PET/CT acquisition was performed with a dedicated scanner and in 10 minutes time per bed position. The images were reconstructed and analyzed with the 3D-OSEM algorithm, applying PSF resolution recovery (TrueX in Syngo ® software, Siemens Medical Solution), 3 iterations, and 21 subsets using a 3 mm Gaussian post-smoothing filter. These data would be potentially beneficial for automatic tumor delineation machine learning as well as for differentiation between an active viable tumor vs. post-surgery/necrosis in indeterminate cases. The theranostics potential (CXCR4-tageted labeled beta emitters) is one of the most novel areas of interest for future studies.本数据集收录了初治成年高级别脑胶质瘤患者中靶向趋化因子受体4（CXCR4）的相关成像信息，所用成像手段为新型放射性标记PET显像剂[68Ga]Ga-CXCR4 PET/CT。入组患者经静脉注射该放射性显像剂，约60分钟后，使用专用扫描仪开展PET/CT采集，每个床位的采集时长为10分钟。图像重建与分析采用3D-OSEM算法，结合PSF分辨率恢复技术（依托西门子医疗解决方案（Siemens Medical Solution）的Syngo®软件中的TrueX模块），设置3次迭代、21个子集，并辅以3mm高斯后平滑滤波。该数据集有望应用于肿瘤自动勾画的机器学习研究，同时可用于鉴别不确定病例中的活动性存活肿瘤与术后改变/坏死。此外，CXCR4靶向标记β发射体的治疗诊断学（theranostics）潜力，是未来研究中最具创新性的热点方向之一。