Construction of antibiotic-induced depression mice model and the function of intestinal microbiota

There are many kinds of research focus on intestinal microbiota-related depression induced by the usage of antibiotics, but the use of antibiotics is pretty different. In order to construct an effective antibiotic-induced depression mice model and explore the effect of intestinal microbiota in antibiotic-induced depression in mice, we used several kinds of antibiotic mixtures to induce mice depression, and then we used depression-related behavioral tests and neurobiological factors to evaluate the construction of the antibiotic-induced depression mice model. Metagenomics analysis and fecal microbiota transplantation (FMT) of intestinal microbiota from antibiotic-induced depression mice were performed to analyze the effect of intestinal microbiota.