CIDR: Molecular Pathological Epidemiology of Colorectal Cancer

Colorectal cancer, the second most commonly diagnosed cancer is a biologically heterogeneous disease. To characterize the molecular attributes of colorectal tumors, we conducted targeted sequencing at the Center for Inherited Disease Research (CIDR) on 4,518 tumor and matched normal DNA samples from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and the Colon Cancer Family Registry (CCFR). These consortia are based on cohort and population-based case-control studies.]]>
Study participants were unrelated adults with colorectal cancer from Australasian Colorectal Cancer Family Study (ACCFR), ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED), Cancer Risk Assessment Study (CRA), Colorectal Cancer Genetics and Genomics (CRCGEN), European Prospective Investigation into Cancer and Nutrition (EPIC Norfolk), the Hispanic Case-Control Study (HCCS), Health Professionals Follow-Up Study (HPFS), Iowa Women's Health Study (IWHS), the Melbourne Case-Control Study (MCCS), Nurses' Health Study (NHS), Nurses' Health Study II (NHSII), and the Prostate, Lung, Colorectal, and Ovarian Cancer study (PLCO). Patient inclusion and exclusion criteria reflected those of the individual studies contributing to this project. Additionally, appendix, anal, carcinoid and in situ colorectal tumors were excluded, as were individuals without consent for submitting data to dbGaP and without sufficient samples available for sequencing.]]>