HOmo sapiens transcription factor COmprehensive MOdel COllection

HOmo sapiens COmprehensive MOdel COllection (HOCOMOCO) v11 provides transcription factor (TF) binding models for 680 human and 453 mouse TFs. Since v11, HOCOMOCO is complemented by MoLoTool, an interactive web tool to mark motif occurrences in a given set of DNA sequences. In addition to basic mononucleotide position weight matrices (PWMs), HOCOMOCO provides dinucleotide position weight matrices based on ChIP-Seq data. All the models were produced by the ChIPMunk motif discovery tool. Model quality ratings are results of a comprehensive cross-validation benchmark. ChIP-Seq data for motif discovery was extracted from GTRD database of BioUML platform, that also provides an interface for motif finding (sequence scanning) with HOCOMOCO models.智人综合模型集合（HOCOMOCO）v11提供了680个人类与453个小鼠转录因子（transcription factor, TF）的结合模型。自v11版本起，HOCOMOCO配套新增了MoLoTool——一款可在给定DNA序列集合中标记基序（motif）出现位置的交互式网络工具。除基础单核苷酸位置权重矩阵（PWMs）外，HOCOMOCO还提供基于染色质免疫共沉淀测序（ChIP-Seq）数据构建的二核苷酸位置权重矩阵。所有模型均由ChIPMunk基序发现工具生成。模型质量评级基于全面交叉验证基准测试的结果。用于基序发现的ChIP-Seq数据提取自BioUML平台的GTRD数据库，该平台同时提供基于HOCOMOCO模型的基序查找（序列扫描）接口。

搜集汇总

背景与挑战

背景概述

HOCOMOCO v11是一个转录因子结合模型集合，提供680个人类和453个小鼠转录因子的单核苷酸与双核苷酸位置权重矩阵。这些模型基于ChIP-Seq数据生成，并包含多种工具和评估方法，支持转录因子结合位点的分析与预测。