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DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

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NIAID Data Ecosystem2026-03-10 收录
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A subset of genomically silent childhood posterior fossa ependymomas show reduced H3K27me3, global DNA hypomethylation, are more invasive, exhibit poor prognosis and epigenetically deregulated genes converge on radial glial factors, suggesting developing cerebellar radial glia as candidate cells-of-origin. Overall design: Quantification of CpG methylation in 3 ependymoma subtypes

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2017-09-17
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