A Phase IA/II Multicenter, Dose-escalation Study of Oral AMN107 on a Continuous Daily Dosing Schedule in Adult Patients With Imatinib-resistant/Intolerant CML in Chronic or Accelerated Phase or Blast Crisis, Relapsed/Refractory Ph+ ALL, and Other Hematologic Malignancies.

The purpose of this trial is to assess the efficacy, safety, tolerability, biologic activity, and pharmacokinetics of AMN107 in six groups of patients with one of the following conditions:Relapsed/refractory Ph+ Acute lymphoblastic leukemia (ALL) (arm 1)Group A - Imatinib failure only (arms 2, 3 and 4)* imatinib-resistant or intolerant CML - Chronic Phase (CP)* imatinib-resistant or intolerant CML - Accelerated Phase (AP)* imatinib-resistant or intolerant CML - Blast Crisis (BC)Group B - Imatinib and other TKI failure (arms 2, 3 and 4)* imatinib-resistant or intolerant CML - Chronic Phase (CP)* imatinib-resistant or intolerant CML - Accelerated Phase (AP)* imatinib-resistant or intolerant CML - Blast Crisis (BC)Hypereosinophilic syndrome/chronic eosinophilic leukemia (HES/CEL) (arm 5)Systemic mastocytosis (Sm) (arm 6)