Integrated multi-cohort single-cell atlas of osteoarthritic chondrocyte remodeling

This dataset contains a processed multi-cohort single-cell RNA-sequencing atlas of osteoarthritic chondrocyte remodeling generated through integration of publicly available osteoarthritis cartilage datasets. The release includes a frozen harmonized single-cell atlas used for manuscript analyses, curated cell-state annotations, dataset and condition summaries, cross-cohort robustness analyses, and transcriptome-informed therapeutic vulnerability prioritization outputs. The principal dataset included in this release is: publication_clean_atlas_FINAL_FROZEN.h5ad This harmonized atlas was used for downstream analyses including: • disease-associated chondrocyte state annotation• branch-specific remodeling trajectory reconstruction• signaling program characterization• transcriptome-informed therapeutic vulnerability prioritization• cross-cohort reproducibility analyses Raw sequencing data are not redistributed in this release and remain available through their original Gene Expression Omnibus (GEO) repositories referenced in the associated manuscript. Included supporting materials: • cell-state annotation tables• dataset and condition summaries• cross-cohort robustness tables• therapeutic vulnerability landscape tables• supporting documentation for reproducibility This release corresponds to the processed atlas version used in the associated manuscript.