Antiviral Potential of β-Caryophyllene: An Exploration in Combating HSV-1 from In-Silico to In-Vitro

1.The raw data from the Surface Plasmon Resonance (SPR) experiments are available as supplementary materials. These data provide detailed information on the binding kinetics between β-Caryophyllene and HSV-1 glycoprotein, including association and dissociation rates. The SPR data are essential for understanding the interaction strength and stability, which are discussed in the manuscript's results section. These materials are available for further analysis and verification through the supplementary files provided with this submission. 2.Microscopic images used for measuring the diameter of viral plaques are available as supplementary materials. These images were captured on days 2 and 3 of the experiment and were utilized to quantify the antiviral effects of β-Caryophyllene by analyzing the plaque reduction across different1. 表面等离子体共振（Surface Plasmon Resonance, SPR）实验的原始数据以补充材料形式公开。该数据详细记述了β-石竹烯（β-Caryophyllene）与单纯疱疹病毒1型（HSV-1）糖蛋白间的结合动力学特征，涵盖结合速率与解离速率两项核心参数。SPR数据是解析二者相互作用强度与稳定性的关键依据，相关内容将在本论文的结果章节中予以讨论。本次提交的补充文件可供后续开展进一步分析与验证工作。 2. 用于测定病毒噬斑直径的显微图像以补充材料形式公开。此类图像采集自实验第2天与第3天，可通过分析不同的噬斑减少情况量化评估β-石竹烯的抗病毒活性。