Imidazole and cyanophenyl farnesyl transferase inhibitors
收藏Protein Data Bank Japan2024-02-14 更新2026-03-21 收录
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https://pdbj.org/mine/summary/1ni1
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资源简介：
Imidazole and cyanophenyl farnesyl transferase inhibitors Descriptor: 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ... Authors: Tong, Y, Lin, N.H, Wang, L, Hasvold, L, Wang, W, Leonard, N, Li, T, Li, Q, Cohen, J, Gu, W.Z, Zhang, H, Stoll, V, Bauch, J, Marsh, K, Rosenberg, S.H, Sham, H.L. Deposit date: 2002-12-20 Release date: 2004-04-06 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability. Bioorg.Med.Chem.Lett., 13, 2003
咪唑与氰苯基类法尼基转移酶抑制剂
描述符：2-氯-5-(3-氯苯基)-6-[(4-氰基苯基)-(3-甲基-3H-咪唑-4-基)甲氧基甲基]烟腈、α-羟基法尼基膦酸、蛋白法尼基转移酶α亚基……
作者：Tong, Y、Lin, N.H、Wang, L、Hasvold, L、Wang, W、Leonard, N、Li, T、Li, Q、Cohen, J、Gu, W.Z、Zhang, H、Stoll, V、Bauch, J、Marsh, K、Rosenberg, S.H、Sham, H.L
提交日期：2002-12-20
发布日期：2004-04-06
最后修改日期：2024-02-14
检测方法：X射线衍射（2.3埃）
引用文献：《发现兼具更佳口服生物利用度的强效咪唑与氰苯基类法尼基转移酶抑制剂》，Bioorg.Med.Chem.Lett., 13, 2003
创建时间：
2002-12-20
