Formation and Conformational Conversion of Flattened Partial Cone Oxygen Bridged Calix[2]arene[2]triazines

A stepwise fragment coupling reaction starting with substituted dichlorotriazine and resorcinol derivatives gave rise to thermodynamically favored 1,3-alternate tetraoxacalix[2]arene[2]triazines and kinetically controlled flattened partial cone tetraoxacalix[2]arene[2]triazines. The flattened partial cone conformer, which was stable due to the steric effect, converted into the 1,3-alternate conformer via ether bond cleavage upon treatment with an inorganic base.以取代的二氯三嗪和邻羟基苯甲醚衍生物为起始物，逐步进行的片段耦合反应，产生了热力学上优化的1,3-交替四氧杂卡利[2]烯[2]三嗪及其动力学上受控的扁平部分圆锥形四氧杂卡利[2]烯[2]三嗪。由于立体效应而稳定的扁平部分圆锥形构象，在无机碱处理下，通过醚键断裂转变为1,3-交替构象。