Data for: Attenuation of DSS Induced Colitis by Dictyophora Indusiata Polysaccharide (DIP) via Modulation of Gut Microbiota and Inflammatory Related Signaling Pathways

In this study, we aimed to determine the therapeutic potential of crude polysaccharide (DIP) that was isolated from the mushroom Dictyophora indusiata in the amelioration of DSS induced colitis. Previously, our research group has reported DIP activity in the restoration of gut microbiota in an antibiotic driven intestinal dysbiosis mouse model. Kanwal, S., Joseph, T., Owusu, L., Xiaomeng, R., Meiqi, L., & Yi, X. (2018). A polysaccharide isolated from Dictyophora indusiata promotes recovery from antibiotic-driven intestinal dysbiosis and improves gut epithelial barrier function in a mouse model. Nutrients, 10(8), 1003. So far numerous biological activities of polysaccharide from the mushroom D.indusiata have been reported, however, to the best of our knowledge, its impact on the DSS induced colitis has not been explored yet. In this study, we investigated the role and contribution of DIP in the attenuation of DSS induced colitis. Our finding revealed a promising effect of DIP in the alleviation of DSS induced colitis and associated symptoms. We believe, that this study will add value in the implication of polysaccharide DIP from the mushroom D.indusiata as dietary therapeutics after detailed pre-clinical and clinical studies.本研究旨在探究从长裙竹荪（Dictyophora indusiata）中分离得到的粗多糖（DIP）对DSS诱导的结肠炎的改善治疗潜力。此前，本研究团队已报道过DIP在抗生素诱导的肠道菌群失调小鼠模型中可恢复肠道菌群的活性。Kanwal S、Joseph T、Owusu L、Xiaomeng R、Meiqi L及Yi X于2018年发表的研究显示，从长裙竹荪中分离得到的多糖可在小鼠模型中促进抗生素诱导的肠道菌群失调恢复，并改善肠道上皮屏障功能，该研究刊载于《Nutrients》2018年第10卷第8期，第1003页。 截至目前，学界已报道了长裙竹荪多糖的多种生物学活性，但据我们所知，其对DSS诱导结肠炎的影响尚未被探究。本研究探究了DIP在缓解DSS诱导结肠炎中的作用与贡献。研究结果显示，DIP在缓解DSS诱导结肠炎及其相关症状方面具有良好的应用潜力。我们认为，本研究将为后续开展深入的临床前与临床试验，将长裙竹荪来源的DIP开发为膳食治疗剂提供研究价值。