MOESM4 of A design–build–test cycle using modeling and experiments reveals interdependencies between upper glycolysis and xylose uptake in recombinant S. cerevisiae and improves predictive capabilities of large-scale kinetic models

Additional file 4. Sheet “Flux Control Coefficients”: (i) Control coefficients of the xylose uptake (XTR) for a set of most important enzymes; (ii) Correlation of the distributions of the XTR control coefficients for HXK, ATPM and ZWF; (iii) The effects of manipulations of HXK, ATPM and NDR on metabolic fluxes. Sheet “Concentration Control Coeffs”: Control coefficients of the cytosolic ATP, cytosolic NADH and cytosolic NADPH during glucose-xylose co-utilization. Sheet “Turnover Control Coefficients”: (i) Turnover control coefficients of cytosolic ATP, mitochondrial ATP, cytosolic NADH, cytosolic NADPH, cytosolic protons and mitochondrial protons for HXK, ATPM and NDR; (ii) Flux control coefficients of producing and consuming reactions of cytosolic ATP, mitochondrial ATP, cytosolic NADH, cytosolic NADPH, cytosolic protons and mitochondrial protons for HXK, ATPM and NDR.