Systematic reviews where a search in industry results registries led to a change in results: statistical details of results and influence on outcomes.

a: AEs, SAEs, treatment-emergent AEs, withdrawals due to AEs.
b. The term used for the primary outcome differs, but the operationalization of outcomes was the same.
c: Inconsistencies between the results of the original SR and the results including reports from industry results registries cannot be fully explained by the different populations analysed (intention to treat vs. randomized).
d: Inconsistencies between the results of the original SR and the results including reports from industry results registries can be explained by the inclusion of an additional trial.
e: Inconsistencies between the results of the original SR and the results including reports from industry results registries noted. However, no data shown as these inconsistencies can be explained by the different populations analysed.
AE: adverse event; CI: confidence interval: HAM-D: Hamilton rating scale for depression; LDL-C: low-density lipoprotein cholesterol; OR: odds ratio; RR: relative risk; SAE: serious adverse events; SR: systematic review; WMD: weighted mean difference.