CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local

CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local Descriptor: (4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic acid, Soluble cytochrome b562,Mas-related G-protein coupled receptor member X4,Green fluorescent protein Authors: Yang, J, Fan, J.P, Lei, X.G. Deposit date: 2023-08-14 Release date: 2024-11-06 Last modified: 2024-12-25 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch. Cell, 187, 2024本数据集为结合激动剂DCA-3P的Gq蛋白偶联MRGPRX4（Mas相关G蛋白偶联受体X4，Mas-related G-protein coupled receptor member X4）的冷冻电镜（CryoEM）结构。局部结构描述：(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-10,13-二甲基-12-羟基-3-膦酰氧基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊并[a]菲-17-基]戊酸；样品包含可溶性细胞色素b562、Mas相关G蛋白偶联受体X4与绿色荧光蛋白（Green fluorescent protein）。作者：杨杰、范建平、雷晓光；存储日期：2023-08-14；发布日期：2024-11-06；最后修改日期：2024-12-25；结构解析方法：电子显微镜（分辨率3.2埃）；引用文献：《基于结构导向发现可治疗肝病且不引发瘙痒的胆汁酸衍生物》，《Cell》，2024年，第187卷。