Enriched Domain Detector: a program for detection of wide genomic enrichment domains robust against local variations

Lamin A ChIP-seq data analyzed using the novel algorithm, Enriched Domain Detector (EDD), for analysis of broad enrichment domains from ChIP-seq data. EDD enables the discovery of genomic domains interacting with broadly distributed nuclear envelope- and chromatin-associated proteins such as lamins. The main advantage of EDD over existing broad peak callers is its sensitivity to domain width rather than enrichment strength at a particular site, and its robustness against local variations.