Background: Glucocorticoids (GCs) cause apoptosis in malignant cells of lymphoid lineage by transcriptionally regulating a plethora of genes. As a result, GCs are included in almost all treatment pro
In this study, we performed a genome-wide CRISPR knockout screen to discover novel MHC-I–specific negative regulators in ovarian cancer. Isoprenylcysteine carboxylmethyltransferase (ICMT) emerged from
(Mean ± SE of 3 independent experiments; MEC = minimum effective concentration; MIC = minimum inhibitory concentration). In vitro microbicidal MIC of pure metronidazole = ∼11 & 340 µM against suscepti