Building Covalent Molecular Capsules by Thiol-Michael Addition Click Reaction

The thiol-Michael
addition (TMA) is a powerful methodology to click
several fragments together, despite having been underestimated in
the synthesis of complex systems for supramolecular chemistry. Herein,
a very fast and efficient method has been developed to make covalent
molecular capsules by taking advantage of the TMA click reaction.
Several scaffolds commonly used in supramolecular chemistry, such
as calixarenes, CTV, or cavitands, have been used to quickly obtain
covalent cages. Additionally, a ‘click&click’ procedure has been also developed, by sequential combination
of TMA and CuAAC click reaction, as an easy and quick way to build
complex molecular structures.