HLE-Inhibitory Alkaloids with a Polyketide Skeleton from the Marine-Derived Fungus Coniothyrium cereale
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The marine endophytic fungus Coniothyrium cereale produces the structurally unusual polyketide-type alkaloids (−)-cereolactam (1) and (−)-cereoaldomine (3), incorporating a lactam and an imine functionality, respectively, as well as the related metabolite (−)-trypethelone (2). Compounds 1 and 3 showed selective inhibition of human leukocyte elastase with IC50 values of 9.28 and 3.01 μM, respectively. Compound 2 was found to be inhibitory toward Mycobacterium phlei, Staphylococcus aureus, and Escherichia coli and also cytotoxic against mouse fibroblast cells (IC50 = 7.5 μM).
创建时间：
2016-02-22
