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Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/Insulin/IGF-receptor pathway

ChEBI2010-06-20 更新2026-07-21 收录

IGF-1信号通路

寿命与低氧适应机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-18601 数据链接链接失效反馈

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Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/Insulin/IGF-receptor pathway

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创建时间：

2010-06-20

神经氧化应激

IGF-1信号通路

Fig1a) Neuron viability measured as percentage of GFP positive cells cultured ± astrocytes after treatment with H2O2. N: neurons, NA: neurons + astrocytes. Names for each file refer to the related fig

NIAID Data Ecosystem100

IGF-1, IGF-1receptor mRNA, and L-[U-14C]-phenylalanine incorporation into proteins, in confluent non-proliferating L6 skeletal muscle cells.

骨骼肌代谢

IGF-1信号通路

Cells were amino acid refed at High AA concentrations (9 mM) with or without presence of inhibitors of molecules in the IGF-1receptor signaling pathway (mean±SE, n = 4-5/group).

NIAID Data Ecosystem40

FOXO and HSF1 rejuvenate immunity via positive feedback regulation of insulin/IGF-1 signaling

免疫衰老

IGF-1信号通路

A hallmark of aging is immunosenescence, a decline in immune function that appeared to be inevitable. Surprisingly, here we show that genetic inhibition of DAF-2/insulin/IGF-1 receptor drastically del

NIAID Data Ecosystem40

Insulin/IGF signaling and vitellogenin provisioning mediate intergenerational adaptation to nutrient stress

跨代营养胁迫适应

IGF-1信号通路

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem80

Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications

结直肠癌分子机制

IGF-1信号通路

We here show that loss of imprinting (LOI) of IGF2 is a frequent and early event in the development of colon cancer and occurs throughout the large intestine. LOI leads to AKT1-dependent activation an

NIAID Data Ecosystem40

Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/Insulin/IGF-receptor pathway

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