Differential Transcriptomic Analysis of Wild Type and Mutant Sindbis Virus Infections of Mice

The data contained in this project includes short-read sequencing data obtained from brain tissue harvested from male and female mice infected with wild type Sindbis virus (strain AR86), a derivative mutant lacking residues in one of the N-terminal domains of the capsid protein, or mock infected via intracranial injection. Tissues were harvested at 3 days post infection and immediately processed to extract total RNA. The total RNA was then utilized to develop cDNA libraries for deep-sequencing to enable the detection of differentially expressed host genes across the three biological conditions.