Biologic parameters for modeling of the CD4⁺ T lymphocyte compartment.

The parameters utilize for modeling CD4+ T lymphocyte turnover and infection using the NPP assumption are listed. For the PP assumption, activated cells were committed to 8 divisions with the same kinetics as CTLs (see Table 2). *Derived constant based on biologically observed steady state value and estimated loss rate of activated cells (see Supplemental Methods). For the programmed proliferation assumption (PP), the value is 1.9×10−4/day. **Derived constant based on biologically observed steady state value and estimated loss rate of total body CD4+ T lymphocytes (see Supplemental Methods). For the programmed proliferation assumption (PP), the value is 2.5×106/day. ***Set constant based on the model yielding timing of peak viremia corresponding to biologically observed timing, and consistent with virion viability ranging from 1∶1 to 1∶1000 [64] and Virion Prod.