PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1

When the proteasome machinery is deregulated, misfolded proteins are eliminated by forming aggresomes. To this end, poly-ubiquitinated misfolded proteins bind to a complex comprising of Transitional endoplasmic reticulum ATPase (VCP), Histone deacetylase 6 (HDAC6), Heat shock protein HSP 90 (HSP90) and Heat shock factor protein 1 (HSF1). HDAC6 in the complex interacts with the ubiquitin molecules in the misfolded proteins. Following this binding event, this complex starts dissociating (Boyault C et al. 2007).

当蛋白质降解系统失调时，错误折叠的蛋白质通过形成蛋白质聚集体被清除。为此，多泛素化的错误折叠蛋白质与由过渡内质网ATP酶（VCP）、组蛋白脱乙酰化酶6（HDAC6）、热休克蛋白HSP 90（HSP90）和热休克因子蛋白1（HSF1）组成的复合物结合。在此复合物中，HDAC6与错误折叠蛋白质中的泛素分子相互作用。在此次结合事件之后，该复合物开始解离（Boyault C et al. 2007）。