Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc

Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc Descriptor: MANGANESE (II) ION, Polypeptide N-acetylgalactosaminyltransferase 2, URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE Authors: de las Rivas, M, Coelho, H, Diniz, A, Lira-Navarrete, E, Jimenez-Barbero, J, Schjoldager, K.T, Bennett, E.P, Vakhrushev, S.Y, Clausen, H, Corzana, F, Marcelo, F, Hurtado-Guerrero, R. Deposit date: 2017-09-12 Release date: 2018-04-11 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts. Chemistry, 24, 2018

GalNAc-T2 F104S突变体与UDP-GalNAc结合的晶体结构。描述项：二价锰离子（MANGANESE (II) ION）、多肽N-乙酰半乳糖胺基转移酶2（Polypeptide N-acetylgalactosaminyltransferase 2）、尿苷二磷酸-N-乙酰半乳糖胺（URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE）。作者：de las Rivas, M、Coelho, H、Diniz, A、Lira-Navarrete, E、Jimenez-Barbero, J、Schjoldager, K.T、Bennett, E.P、Vakhrushev, S.Y、Clausen, H、Corzana, F、Marcelo, F、Hurtado-Guerrero, R。沉积日期：2017-09-12；发布日期：2018-04-11；最后修改日期：2024-11-06。测试方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.7 Å。引用文献：《GalNAc-T2突变体的结构分析揭示GalNAc-T家族的诱导契合催化机制》，刊载于*Chemistry*，2018年，第24卷。