Proteome and Phosphoproteome of Circulating Extracellular Vesicles in Type 1 Diabetes and Controls

This pilot study aimed to characterize the proteomic and phosphoproteomic landscape of circulating EVs in participants with established T1D (N=10) and healthy normal volunteers (Controls) (N=7) (NCT03379792) carefully matched by age, race/ethnicity, sex, and BMI. EVs were isolated using EVtrap® technology. EV proteins identified and quantified by LC-MS analysis.