WuTou Decoction Ameliorates Knee Osteoarthritis by Modulating Gut Microbiota and Metabolic Profile

Knee Osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by cartilage degradation and synovial inflammation, leading to severe joint dysfunction. WuTou Decoction (WTD) is a classic traditional Chinese medicine formula for treating joint pain, but its specific mechanism is not clear. To investigate the therapeutic effectsand mechanism analysis of WTD in KOA rats by gut microbiota and metabolism.