Expression data from cerebrum in a spontaneous mutant mouse, laggard.

We found a new spontaneous mutant mouse, laggard, characterized by general weakness in movements and retardation in growth. We used microarray to identify genes whose expression levels are affected downstream from the mutation. RNA was extracted from the cerebrum of each mutant mouse or its littermate, performing hybridization to Affymetrix DNA chip with cRNA probe. The profiles were compared comprehensively between them to investigate the molecular pathology in the mutant mouse.