BVDV-induced immune modulation and thymic adaptation in calves

This study performed RNAseq transcriptomic profiling of thymus tissue from 19 colostrum-deprived calves to define gene expression programs associated with BVDV-2 (RS886)-induced thymic injury and recovery. Calves were assigned to mock controls and BVDV-infected calves necropsied at 13 dpi, and to a second time-matched set necropsied at day 42, consisting of calves infected only with influenza D virus (IDV) versus calves previously infected with BVDV and later challenged with IDV.