Gene expression profile at single cell level of lung-tumor bearing KrasG12D mice with or without defective cholesterol efflux

Impaired cholesterol efflux pathways is a hallmark of lung adenocarcinoma. We used single cell RNA sequencing (scRNA-seq) to analyze the impact of defective cholesterol efflux on cell diversity in lung tumor Lung cells were disociated by proteolytic digestion with collagenase D from whole lung (n=3/4 mice per group)