Comprehensive analysis of disease pathology in immunocompetent and immunocompromised hamster models of SARS-CoV-2 infection

Distinct changes in host inflammation and immune cell response pathways and networks were seen in the lung transcriptome of infected immunocompetent and immunocompromised animals, consistent with their differing disease presentation. This report highlights the interplay between the kinetics of viral replication and the dynamics of SARS-CoV-2 pathogenesis at organ-level niches and maps how COVID-19 symptoms vary in different immune contexts